CAOPORN成人免费公开,欧美FREESEX黑人又粗又大 ,欧美狠狠入鲁的视频777色,主仆调教SM束缚绳索捆绑

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
99久久国产宗和精品1上映,大尺度做爰视频吃奶WWW,日本强好片久久久久久AAA
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-HPV16 E7  antibody (bs-0714R)
~~~促銷代碼KT202409~~~
訂購熱線:400-901-9800
訂購郵箱:sales@www.tjshangbang.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@www.tjshangbang.com
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-0714R
英文名稱 Rabbit Anti-HPV16 E7  antibody
中文名稱 人乳頭瘤病毒16型E7抗體
別    名 E7; HPV16 E7 protein; HPV 16 E7 protein; Human Papilloma Virus; Human papillomavirus type 16 E7; Human papillomavirus type 16 E7; Protein E7; Human Papillomavirus 16 (E7); HPV16 E7; E7 protein (HPV16); VE7_HPV16; HPV16-E7.  
Specific References  (3)     |     bs-0714R has been referenced in 3 publications.
[IF=4.848] Tang Jia-Yi. et al. HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation. Front Oncol. 2020 Nov;10:2470  WB ;  Human.  
[IF=4.257] Hong-Miao Wang. et al. HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells:. Ther Adv Chronic Dis. 2020;():  WB ;  Human.  
[IF=3.182] NJ Gu et al. HPV 16 E6/E7 up-regulate the expression of both HIF-1α and GLUT1 by inhibition of RRAD and activation of NF-κB in lung cancer cells. Journal of Cancer 2019; 10(27): 6903-6909.  WB ;  Human.  
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) HPV16
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,Flow-Cyt=1ug/Test,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 11kDa
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from HPV16 E7 protein: 41-90/98 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Function:
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription.

Subunit:
Homodimer. Homooligomer. Interaction with host RB1 induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Binds to CHD3 through its zinc-finger domain. Forms a complex with CHD3 and HDAC1, thereby altering the action of host histone deacetylation. A similar complex involving E7, CHD3 and HDAC2 might also form. Interacts with E2; this interaction inhibits E7 oncogenic activity.

Similarity:
Belongs to the papillomaviridae E7 protein family.

SWISS:
P03129

Gene ID:
1489079

Database links:

Entrez Gene: 1489079 HPV16

SwissProt: P03129 HPV16




E7/E6protein抗體主要用于性病及婦科腫瘤方面的研究,HPV16是宮頸癌的主要致癌病毒,也用于與HPV有關(guān)的各種腫瘤的研究。表達(dá)位置:胞核。陽性細(xì)胞也可見于角蛋白層,尤其是在疣中。該抗體用于人類生殖系統(tǒng)傳染性疾病及其腫瘤的研究,亦可用于食管癌、乳腺癌等惡性腫瘤的研究。
產(chǎn)品圖片
Sample: Lane 1: Recombinant HPV16 E7 protein Bacterial lysate, DsbC & His(bs-49101L) Primary: Anti-HPV16 E7 (bs-0714R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 11 kDa Observed band size: 61 kDa
Tissue/cell: human breast cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-HPV16-E7 Polyclonal Antibody, Unconjugated(bs-0714R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Blank control: Hela. Primary Antibody (green line): Rabbit Anti-HPV16 E7 antibody (bs-0714R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
版權(quán)所有 2004-2026 www.www.tjshangbang.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
欧美视频不卡一区二区三区| 后入人妻中文字幕| 亚洲无线观看| 丰满熟妇乱又伦在线无码视频| 欧美mv日韩mv亚洲精品| 熟妇人妻无乱码中文字幕真矢织江| 99精品国产美女福到在线不卡| 久久综合欧美成人| A级毛片无码久久精品免费| 无码专区视频精品老司机| 西西人体大胆瓣开下部自慰| WWW插插插无码视频网站| 久操精品在线观看| 国产精品无码专区| 亚洲午夜精品久久久久久app| 刺激的乱亲小说43部分阅读| YW尤物AV无码国产在线观看| 国产精品不卡片视频免费观看| 日本理论片韩国理论片免费看| 精品一区二区三区免费毛片爱| 亚洲第一福利视频| 免费看国产日韩| 宝贝小嫩嫩好紧好爽H在线视频| 最爽无遮挡行房视频| 欧美福利二区| 欧美精产国品一二三类产品特点| 精品久久无码中文字幕| 三周年思念天堂的老公| 欧美亚洲国产精品久久高清| 国内精品人妻无码久久久影院| 高清欧美视频一区二区三区| 狠狠躁夜夜躁人人爽天天BL| 亚洲 日韩 另类 制服 无码| 国产欧美一区二区精品久久久| 亚洲人成无码网WWW电影麻豆| 国产在线精品观看一区| 丰满少妇a级毛片| 久久久久国产一区二区三区| 亚洲日韩国产精品乱| 热精品韩国毛久久久久久| 欧美xxxx做受性欧美88|