| 產(chǎn)品編號(hào) | bs-1197R |
| 英文名稱 | Rabbit Anti-TLR5 antibody |
| 中文名稱 | Toll樣受體5抗體 |
| 別 名 | toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3;CD285; TLR5_MOUSE. |
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Specific References (6) | bs-1197R has been referenced in 6 publications.
[IF=5.959] Shi D et al. TLR5: A prognostic and monitoring indicator for triple-negative breast cancer. Cell Death Dis. 2019 Dec 18;10(12):954. IHC ; Mouse.
[IF=4.26] Li, Chengcheng, et al. "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." Scientific Reports 7 (2017). WB ; Mouse.
[IF=3.829] Wang Ruibiao. et al. Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function. VET RES. 2022 Dec;53(1):1-11 WB ; Pig.
[IF=3.7] Sun, Hukui, et al. "Non‐invasive imaging of allogeneic transplanted skin graft by 131I‐anti‐TLR5 mAb." Journal of Cellular and Molecular Medicine (2014). IHC-P ; Mouse.
[IF=3.42] Hao, Jing, et al. "rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner." Cellular & molecular immunology (2013). WB ; Mouse.
[IF=2.25] Sun, H., et al. "In vivo Toll‐like receptor 5 (TLR5) imaging with radiolabeled anti‐TLR5 monoclonal antibody in rapamycin‐treated mouse allogeneic skin transplantation model." Transplant Infectious Disease (2015). IHC-P ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 95kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse TLR5: 701-810/873 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Subunit: Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Highly expressed in liver. Detected in lung and at very low levels in most other tissues. Post-translational modifications: Phosphorylated at Tyr-799 upon flagellin binding; required for signaling (By similarity). Similarity: Belongs to the Toll-like receptor family. Contains 16 LRR (leucine-rich) repeats. Contains 1 TIR domain. SWISS: Q9JLF7 Gene ID: 53791 Database links: Entrez Gene: 7100 Human Entrez Gene: 53791 Mouse Omim: 603031 Human SwissProt: O60602 Human SwissProt: Q9JLF7 Mouse Unigene: 604542 Human Unigene: 116894 Mouse Toll樣受體5可在單核細(xì)胞、未成熟樹突狀細(xì)胞及上皮細(xì)胞表達(dá) ,可能是一種參與免疫應(yīng)答的受體 ,其具體作用尚不清楚。 TLR5可辨認(rèn)鞭毛蛋白(fla-gellin),此種蛋白可組成鞭毛,與細(xì)菌泳動(dòng)有關(guān). |
| 產(chǎn)品圖片 |
Sample:
Liver (Mouse) Lysate at 40 ug
Ovary (Mouse) Lysate at 40 ug
Primary: Anti-TLR5 (bs-1197R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 95 kD
Observed band size: 130 kD
Sample:
Raw264.7(Mouse) Cell Lysate at 30 ug
Hela(Human) Cell Lysate at 30 ug
Primary: Anti-TLR5 (bs-1197R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 95 kD
Observed band size: 130 kD
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