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Rabbit Anti-5HT2A Receptor  antibody (bs-12049R)
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產品編號 bs-12049R
英文名稱 Rabbit Anti-5HT2A Receptor  antibody
中文名稱 5-羥色胺受體2A抗體
別    名 5HT2A_HUMAN; 5-hydroxytryptamine receptor 2A; HTR2A; HTR2; 5-HT-2; 5-HT-2A; Serotonin receptor 2A;  
Specific References  (1)     |     bs-12049R has been referenced in 1 publications.
[IF=3.395] Yue-Xin Li. et al. Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress:. Mol Pain. 0;():  WB ;  Rat.  
研究領域 心血管  細胞生物  神經生物學  細胞膜受體  G蛋白偶聯(lián)受體  新陳代謝  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat (predicted: Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human 5HT2A Receptor: 51-150/471 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.

Subunit:
Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.

Subcellular Location:
Cell membrane. Localizes to the post-synaptic thickening of axo-dendritic synapses.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P28223

Gene ID:
3356

Database links:

Entrez Gene: 3356 Human

Entrez Gene: 15558 Mouse

Entrez Gene: 29595 Rat

Omim: 182135 Human

SwissProt: P28223 Human

SwissProt: P35363 Mouse

SwissProt: P14842 Rat

Unigene: 654586 Human

Unigene: 72630 Human

Unigene: 214351 Mouse

Unigene: 10294 Rat

Unigene: 146756 Rat



產品圖片
Sample: Small intestine (Mouse) Lysate at 40 ug Primary: Anti-5HT2A Receptor (bs-12049R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD
Sample:Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-5HT2A Receptor (bs-12049R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD
Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-5HT2A Receptor (bs-12049R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 50 kD
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