CAOPORN成人免费公开,欧美FREESEX黑人又粗又大 ,欧美狠狠入鲁的视频777色,主仆调教SM束缚绳索捆绑

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
久久精品熟女亚洲AV麻豆,国产午夜视频在线观看
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Mouse Anti-SARS-CoV-2 (2019-nCoV) Spike RBD  antibody (bsm-41637M)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@www.tjshangbang.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@www.tjshangbang.com
說(shuō)明書(shū): 100ug  
100ug/3600.00元
大包裝/詢(xún)價(jià)

產(chǎn)品編號(hào) bsm-41637M
英文名稱(chēng) Mouse Anti-SARS-CoV-2 (2019-nCoV) Spike RBD  antibody
中文名稱(chēng) SARS冠狀病毒2 Spike RBD單克隆抗體
別    名 SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2.  
研究領(lǐng)域 細(xì)菌及病毒  
抗體來(lái)源 Mouse
克隆類(lèi)型 Monoclonal
克 隆 號(hào) 5E8
交叉反應(yīng) SARS-CoV-2
產(chǎn)品應(yīng)用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 140kDa
性    狀 Liquid
濃    度 Lot Dependent
免 疫 原 Recombinant SARS-CoV-2 Spike S1 Protein: 14-685/1213 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M PBS(pH7.4)
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

Function:
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

Subunit:
Spike glycoprotein:
Homotrimer; each monomer consists of a S1 and a S2 subunit (PubMed:32155444, PubMed:32075877). The resulting peplomers protrude from the virus surface as spikes (By similarity).
Interacts with the accessory proteins 3a and 7a.
Spike protein S1:
Binds to human ACE2.

Subcellular Location:
Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;
Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.

Tissue Specificity:
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.
Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).
Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface.

SWISS:
P0DTC2

Gene ID:
43740568

產(chǎn)品圖片
Direct ELISA was used to detect the binding ability of anti-RBD monoclonal antibody to RBD domain proteins of different SARS-CoV-2 Mutant Strains. Immobilized SARS-CoV-2 RBD proteins, at 2μg/ml (100ul/Well) can bind Anti-RBD monoclonal antibody-HRP at 10ug/ml (100ul/Well).
版權(quán)所有 2004-2026 www.www.tjshangbang.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
无码视频免费一区二三区| 欧美特黄一区二区三区| 欧美日韩国产在线人| 精品福利一区二区三区免费视频| 偷柏自拍亚洲综合在线| 日本亚洲色大成网站WWW| 电影甜性涩爱| 小小的日本在线观看免费高清| 久久精品国产亚洲AV麻豆| WWW夜片内射视频日韩精品成人| 欧美人成在线观看ccc36| 亚洲AV无码不卡私人影院| 日韩欧美偷拍一区二区三区| 国产又猛又黄又爽| 国产精品久久久久久精| 国产在线精品无码不卡手机免费| 欧美日韩一级一区二区三区| 综合图区亚洲欧美另类图片| 男人天堂久久久久| 欧美日韩热久久| 亚洲色大成网站WWW尤物| 极品粉嫩小泬白浆20PA片| 果冻传媒免费观看4399| 亚洲AV日韩AV天堂一区二区三区| 天堂中文最新版在线中文| 99精品人妻无码专区在线视频区| 亚洲人成网站999久久久综合| 亚洲欧美日韩国产综合91| 女同视频一区二区在线观看| 伦理电影亚洲国产| 欧美日韩二区高清| 国产男人av天堂| 欧美日韩一区二区三区麻豆| 久久久国产精品亚洲一区| 丰满少妇三级全黄| 侵犯人妻中文字幕| 亚洲精品成人无限看| 亚洲天堂av一区二区三区| 一道精品视频一区二区三区男同| 少妇饥渴偷公乱口述| 国产精品久久久久……|