| 產(chǎn)品編號 | V3705 |
| 英文名稱 | Human sST2 Mouse mAb |
| 中文名稱 | 人生長抑素受體2單克隆抗體 |
| 別 名 | somatostatin receptor 2; Somatostatin receptor type 2; SRIF1; SS2R; SST2; SSTR2; SRIF-1; SS-2-R; SS2-R; SSR2_HUMAN. |
| 克 隆 號 | 5H4 |
| 理論分子量 | 41 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | PBS (pH7.4). |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Somatostatin is a tetradecapeptide that is widely distributed in the body and is one of five receptor subtypes termed SSTr1-. These receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as wel as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptos are activated via sonatostatin secreted by nerve and endocrine cells. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively. Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. Subunit: The C-terminus interacts with SHANK1 PDZ domain. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P30874 Gene ID: 6752 Database links: Entrez Gene: 6752 Human Entrez Gene: 20606 Mouse Omim: 182452 Human SwissProt: P30874 Human SwissProt: P30875 Mouse Unigene: 514451 Human Unigene: 454968 Mouse Unigene: 202974 Rat Unigene: 9929 Rat SSTR2的表達(dá)在腫瘤的分布、發(fā)生和發(fā)展中起重要作用。目前主要用于腫瘤方面的研究。 |
