| 產(chǎn)品編號 | V9001 |
| 英文名稱 | Human Thyroglobulin Mouse mAb |
| 中文名稱 | 人甲狀腺球蛋白單克隆抗體 |
| 別 名 | THYG_HUMAN; TG; AITD 3; AITD3; hTG; TDH3; Tgn |
| 克 隆 號 | 1B5 |
| 理論分子量 | 660 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 純 度 | >90% as determined by SDS-PAGE |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients. SWISS: P01266 Gene ID: 7038 用作生產(chǎn)碘化甲狀腺激素甲狀腺素（T4）和三碘甲狀腺素（T3）的底物。 T3和T4的合成涉及對TG /甲狀腺球蛋白的選定酪氨酸殘基加碘，然后在甲狀腺濾泡內(nèi)腔中進(jìn)行氧化偶聯(lián)。 在TG重新內(nèi)在化和溶酶體介導(dǎo)的蛋白水解之后，T3和T4從多肽主鏈釋放，導(dǎo)致它們分泌到血液中。 一個二聚體產(chǎn)生7個甲狀腺激素分子。 |
