CAOPORN成人免费公开,欧美FREESEX黑人又粗又大 ,欧美狠狠入鲁的视频777色,主仆调教SM束缚绳索捆绑

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
天干天干天啪啪夜爽爽AV,噼里啪啦国语版在线观看
Rabbit Anti-Pokemon/ZBTB7A/Cy5.5 Conjugated antibody (bs-0891R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@www.tjshangbang.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@www.tjshangbang.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0891R-Cy5.5
英文名稱1 Rabbit Anti-Pokemon/ZBTB7A/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的撲克蒙蛋白抗體
別    名 Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI-1; FBI1; HIV-1 1st-binding protein 1; Leukemia/lymphoma related factor; LRF; Pokemon; TIP21; TTF-I interacting peptide 21; ZBTB7; ZBTB7A; Zinc finger and BTB domain-containing protein 7A; ZBT7A_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  微生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pokemon
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.

Function:
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.

Subunit:
Interacts with BCL6.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).

Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.

Database links:

Entrez Gene: 51341 Human

Entrez Gene: 16969 Mouse

Omim: 605878 Human

SwissProt: O95365 Human

SwissProt: O88939 Mouse

Unigene: 591384 Human

Unigene: 20920 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Pokemon(7APOK Erythroid Myeloid Ontogenic factor)能夠控制將正常細(xì)胞變成癌細(xì)胞所需的途徑,Pokemon蛋白是轉(zhuǎn)錄因子蛋白家族的一員,并且在人類癌癥中發(fā)生了突變。另外Pokemon蛋白作為轉(zhuǎn)錄因子參與一些細(xì)胞基因轉(zhuǎn)錄的調(diào)節(jié),并在細(xì)胞分化過程中發(fā)揮著關(guān)鍵、多效性的功能。近來發(fā)現(xiàn),Poke-mon在致癌轉(zhuǎn)化過程中發(fā)揮著至關(guān)重要的功能,并與腫瘤的發(fā)生密切相關(guān)。
這種蛋白很可能在實(shí)質(zhì)腫瘤中處于重要地位,還有學(xué)者認(rèn)為:Pokemon在一定類型的B細(xì)胞和T細(xì)胞淋巴瘤中水平非常高,并發(fā)現(xiàn)具有高水平Pokemon蛋白表達(dá)對腫瘤惡性程度改變更大。
主要定位于細(xì)胞核。
撲克蒙”蛋白又稱“波克曼”蛋白。
版權(quán)所有 2004-2026 www.www.tjshangbang.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
欧美三级日本三级韩国三级| 无码国产伦一区二区三区视频| 国产精品久久久久久妇女| 亚洲人午夜射精精品日韩| 96精品专区国产在线观看高清| 国产精品成年片在线观看| 国产精品黄p在线免费观看| 亚洲国产精品VA在线看黑人| 久久久一本精品99久久精品88| 超碰日本爆乳中文字幕乱码| 内射老妇BBWX0C0CK| 小丹乖让我再进去一次的导演是谁| 免费少妇荡乳情欲视频| 成在线人永久免费视频播放| 日韩 欧美 国产一区二区| 欧美老人巨大XXXX做受| 完美世界在线观看| 99久久久国产精品免费无卡顿| 国产一区二区精品久久 | 日韩一区二区在线视频| 999.com男人天堂| 久久青青草原国产毛片| 久久人人爽人人人人爽AV| 久草免费福利资源站在线观看| 精品国产乱码一区二区三区| 国产对白老熟女正在播放| 年轻的母亲韩国理论片| 舌头伸进去搅动好爽视频| 无码人妻精品一区二区三| 双性美人受哭酸深捣H| 人妻体内射精一区二区三区| 久久久久亚洲AV无码专区首JN| 色妞欧美日韩在线| 日韩国一级电影| 西西人体44| 韩国年轻的妈妈相亲高清视频| 五月丁香啪啪| 男同桌上课用手指进去了好爽| 久热精品视频在线观看99小说| 精品人人妻人人澡人人爽牛牛| 国产女主播喷水视频在线观看|